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1,1'-Carbonyldiimidazole 530-62-1

November 30, 2023


CAS: 530-62-1
Molecular formula: C7H6N4O
Molecular weight: 162.15
Appearance: white to off-white powder, purity ≥99%, melting point 119.6-120.3°C.

Carbonyldiimidazole is a compound with strong reactivity. It can react with functional groups such as -COOH, -NH₂, and -OH to synthesize many ketones, esters, ureas and other compounds that are difficult to obtain by ordinary methods. As a strong activator, CDI has been increasingly studied in the biological field. According to reports, CDI has been used to synthesize protein A immunoadsorbent materials that can be used for liquid aspiration and purification. CDI can be used to modify proteins after activating polyethylene glycol. Because CDI is highly selective as an activator, it has obvious advantages in the synthesis and modification of polymers, especially in the preparation of regular dendritic polymers. With the continuous development of the polymer field, it is expected to receive further development in the field of polymer synthesis research and industrialization. Carbonyldiimidazole is also an important pharmaceutical intermediate, widely used as enzyme and protein binders, antibiotic synthetic drug intermediates, imidazole drug intermediates, especially it can also be used as a bonding agent for the synthesis of polypeptide compounds.

The commonly used synthesis route is to use imidazole and hexamethyldisilazane as starting materials, obtain trimethylsilimidazole through condensation, and then react with triphosgene to obtain the product carbonyldiimidazole.


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#1,1'-Carbonyldiimidazole #530-62-1 


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